丰满老妇高潮一级A片,特级婬片A片AAA毛片咕噜咕噜 ,特级BBBBBBBBB视频,国产黄色免费网站
最近搜索：細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>白細(xì)胞介素4受體抗體
白細(xì)胞介素4受體抗體
  • 產(chǎn)品貨號：
    BN40728R
  • 中文名稱：
    白細(xì)胞介素4受體抗體
  • 英文名稱：
    Rabbit anti-IL-4R Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40728R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:protein) 推薦應(yīng)用：WB

  • BN40728R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:protein) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱IL-4R
中文名稱白細(xì)胞介素4受體抗體
別    名CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  細(xì)胞膜受體  細(xì)胞表面分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
細(xì)胞定位細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IL-4R:71-170/825 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Subunit:
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Post-translational modifications:
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain.

SWISS:
P24394

Gene ID:
3566

Database links:

Entrez Gene: 3566 Human

Omim: 147781 Human

SwissProt: P24394 Human

Unigene: 513457 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


少妇的嫩苞一级A片 | 久久婷婷五月综合色精品 | 欧美一区二区在线观看 | 一级卖婬片A片AAAA鲁大师 | 三上悠亚激情AV一区二区三区 | 免费 国产 无码99久久久 | 久久久人成精品色情 | 中文字幕AV在线观看 | 免费国产又硬又粗视频 | 国产丰满人妻被粗毛片 | 久久成人毛片又大又黄又粗又硬 | 亚洲无码AV一区二区 | 乱色熟女人妻字幕一区 | 国产69精品久久久久熟女白洁 | 国产又粗又猛又爽又黄的 | 五十路熟妇亚洲AV无码 | 污污的视频免费在线观看 | 极品少妇勾引在线观看 | 一级无码婬片A片久久久自慰软件 | 丰满老女人A片免费观看 | 国产一区二区三区三区在线观看 | 国产高清无码不卡黄色电影 | 人妻无码аⅴ天堂中文在线 | 扣逼自慰白浆无码在线 | 狠狠cao日日穞夜夜穞 | 波多野结衣无码aV在线播放 | 国产中文字日产幕乱久久九九 | 91人妻无码精品一区二区 | 黄色高清免费视频在线观看 | 国模私拍一区二区三区 | 国产AV久久久海角社区 | 精品人妻少妇嫩草Av | 亚洲无码久久综合 | 人妻日韩精品中文字幕 | www.国产中文字幕 | 法国少妇色情影片在线 | AV无码秘蜜桃成人片玉蝶直播 | 国精品无码一区二区三区在线秋菊 | 成人短视频在线观看 | 熟女少妇人妻白浆一区二区偷拍 | 免费无码婬片aaaa |